Background: Cholangiocarcinoma is the second-largest liver cancer, and develops from
the biliary epithelium, where it discretely progresses. Unfortunately, many patients miss the opportunity
of performing surgery when diagnosed with cholangiocarcinoma, and due to its chemotherapeutic
insensitivity, its control has always been considered difficult.
Objective: Here, we present a case of stage 4 cholangiocarcinoma being controlled by the combination
of chemotherapy with PD-1 and VEGF/VEGFR2 inhibitors.
Case Presentation: The patient is a 58-year-old male who was diagnosed with a progressed cholangiocarcinoma
2 years ago. From the beginning, metastases were discovered in multiple places, and
the patient was unsuccessfully treated with 3 chemotherapy regimens. Therefore, a new therapeutic
method was considered, and that involved the testing of a new combination of chemotherapy with
PD-1 and VEGF/VEGFR2 inhibitors.
Results: After 6 courses of treatment with this combination, the patient’s lesions became smaller
Conclusion: Our case highlights the possibility of combining chemotherapy with PD-1 and VEGF/
VEGFR2 inhibitors for the treatment of cholangiocarcinoma patients. This combination may herald
new hope for patients who run out of regimens.