Gastrointestinal Bleeding Associated With Warfarin and Rivaroxaban Therapy in Atrial Fibrillation Cases with Concomitant Coagulopathy

(E-pub Ahead of Print)

Author(s): Meghdad Sedaghat, Behnam Safarpour Lima, Reihanesadat Bouzari, Sarvenaz Shadlou*

Journal Name: Cardiovascular & Hematological Disorders-Drug Targets
Formerly Current Drug Targets - Cardiovascular & Hematological Disorders


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Abstract:

Background: There is inadequate information on the risk of gastrointestinal (GI) bleeding in patients who are un-der rivaroxaban and warfarin therapy in Iran. Determining the risk of GI bleeding in patients receiving these two drugs can help to select a more appropriate anti-coagulation prophylaxis in high-risk patients.

Objective: The aim of this study was to compare the incidence of GI bleeding in patients with atrial fibrillation (AF) and concomitant bleeding risk factors receiving either warfarin or rivaroxaban.

Methods: In this observational study, 200 patients with AF and bleeding risk factors who referred to Imam Hossein Hospital (Tehran, Iran) were included. The patients were under treatment with either warfarin or rivaroxaban. The incidence of GI bleeding was compared between the two groups monthly for one year.

Results: GI bleedings were observed in 61% and 34% of patients treated with warfarin and rivaroxaban, respectively (P = 0.001). Melena was the most common type of GI bleeding in both groups. History of hypertension, history of stroke, con-sumption of anti-platelet drugs, NSAID consumption, and history of alcohol consumption were associated with more fre-quent GI bleeding only in warfarin group.

Conclusion: The incidence of GI bleeding was lower in AF patients who received rivaroxaban compared to those treated with warfarin. Also, GI bleeding risk does not change according to the consumption of other anti-coagulant drugs and un-derlying history of hypertension or stroke in patients received rivaroxaban. Therefore, rivaroxaban is suggested as the choice of prophylaxis in patients with AF and concomitant coagulopathy.

Keywords: Atrial fibrillation; Treatment; Gastrointestinal bleeding; Coagulopathy

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Article Details

Published on: 31 December, 2020
(E-pub Ahead of Print)
DOI: 10.2174/1871529X20999201231210044
Price: $95

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