Background: For the past 70 years, the focus of research is towards the search for poisons and toxins found in
venomous and poisonous organisms which is purely directed towards the pharmacological properties of the toxins. In the
research of finding novel compounds in pharmaceutical research, the identified source was the piscine venom.
Objective: Scorpanidae family was considered the most venomous of all. The toxins isolated from stonefish and lionfish are
responsible for the effects caused in cardiovascular and neuromuscular systems and also in causing cytolytic activities. The
main objective of the review is to study the mechanism of the stone fish venom and portray its benefits in the field of drug
Methods: A study on the mechanism of stone fish venom was carried out by inducing cardiovascular endothelium. The
release of neurotransmitter signals thus leads to the depolarisation of cell membrane by the formation of pores in the cell
membrane in neuromuscular system of rabbits, porcine artery, mice and rats. Lionfish venom in cross reactivity with the
results evolved from a stonefish venom activity. The presence of enzymatic hyaluronidase in the primary structures of
lionfish has evolved from stonefish and their anticancer potential has also been demonstrated for the benefits of drug
discovery as they possess biological and chemical activity.
Conclusion: This review depicts an overview on the pharmacological activities of lionfish venom in comparison with the
stonefish venom and their purpose on applications for future research in drug discovery.