Iso-octenidine: Promising Octenidine Analogue with Improved Solubility

Author(s): Igor K. Yakuschenko, Nataliya N. Pozdeeva, Viktoriya A. Mumyatova, Alexey A. Terentiev, Svyatoslav Ya. Gadomsky*

Journal Name: Current Organic Synthesis

Volume 18 , Issue 5 , 2021


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Abstract:

Iso-octenidine, an isomer of octenidine dihydrochloride, was synthesized and studied for the first time. Iso-octenidine was demonstrated to be 3-fold more soluble in water in comparison to original octenidine, and both substances had remarkably similar antibacterial activity (tested on Escherichia Coli and Micrococcus luteus).

Keywords: Octenidine dihydrochloride, bispyridinium salts, alkylation reaction, organic synthesis, solubility, antibacterial activity.

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Article Details

VOLUME: 18
ISSUE: 5
Year: 2021
Published on: 30 December, 2020
Page: [443 - 445]
Pages: 3
DOI: 10.2174/1570179417666201231104453
Price: $65

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