Background: Hypertension is a high prevalent chronic disease worldwide and a major cardiovascular risk factor.
Oleanolic acid (3β-hydroxy-olea-12-en-28-oic acid) is a wide distributed bioactive pentacyclic triterpenoid with diverse
biological activities such as anti-inflammatory, hepaprotective anti-diabetic or anti-hypertensive.
Objective: The aim of this study was to review and highlight the available data about antihypertensive activity of oleanolic
acid and the described mechanisms of action.
Method: Extensive searches were made in the available literature on oleanolic acid and the data investigating its
antihypertensive effects were analysed.
Results: Most of research has been performed on animal models of hypertension, ex vivo studies with aortic ring and some in
vitro tests with cell cultures, whereas clinical trials are still lacking. Treatment of hypertensive animals with oleanolic acid
significantly ameliorated the rise in the systolic blood pressure. In addition, the hypotensive effects of oleanolic acid are also
related to a potent diuretic-natriuretic activity and nephroprotection. In vitro studies have characterized the participation of
various signalling pathways that modulate the release of vasodilation mediators.
Conclusion: In vitro and in vivo studies suggest that oleanolic acid effectively reduce blood pressure and could be an
interesting co-adjuvant to conventional treatment of hypertension.