Potential Non-coding RNAs from Microorganisms and their Therapeutic Use in the Treatment of Different Human Cancers

Author(s): Raju Biswas, Dipanjana Ghosh, Bhramar Dutta, Urmi Halder, Prittam Goswami, Rajib Bandopadhyay*

Journal Name: Current Gene Therapy

Volume 21 , Issue 3 , 2021


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Abstract:

Cancer therapy describes the treatment of cancer, often with surgery, chemotherapy, and radiotherapy. Additionally, RNA interference (RNAi) is likely to be considered a new emerging, alternative therapeutic approach for silencing/targeting cancer-related genes. RNAi can exert antiproliferative and proapoptotic effects by targeting functional carcinogenic molecules or knocking down gene products of cancer-related genes. However, in contrast to conventional cancer therapies, RNAi based therapy seems to have fewer side effects. Transcription signal sequence and conserved sequence analysis-showed that microorganisms could be a potent source of non-coding RNAs. This review concluded that mapping of RNAi mechanism and RNAi based drug delivery approaches is expected to lead a better prospective of cancer therapy.

Keywords: Cancer therapy, RNA interference, carcinogenic, microorganisms, drugs delivery, RNAi based therapy.

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Article Details

VOLUME: 21
ISSUE: 3
Year: 2021
Published on: 30 December, 2020
Page: [207 - 215]
Pages: 9
DOI: 10.2174/1566523220999201230204814
Price: $65

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