Background and Objective: With the initial case of corona reported from Wuhan, China on 31st December 2020,
there has been an unprecedented rise in the coronavirus disease (COVID-19), with over 200 countries all across the world in
less than 3 months. By the October 2020, about 40 million population of the world got infected and over one million deaths
occurred. Since no WHO and FDA approved medications or vaccines for COVID-19 were available, there was an impatient
bustling need to develop a drug for the treatment. Drug repurposing emerged as the easiest and fast emerging strategy to get
medicine for COVID-19 with rapid approvals for the clinical trials. The purpose of this study was to evaluate the status of
drug repurposing under the clinical and its impact for the development of medicine for COVID-19.
Methodology: The study was undertaken to review various clinical trials from www.clinicaltrials.gov website. We
evaluated 220 ongoing clinical trials with the strategy of ‘drug repurposing’ against COVID-19, analyzed them as per their
chemical structure and possible biological targets.
Results: It was noticed that some of the early repurposed drugs like chloroquine, hydroxychloroquine, ACE inhibitors and
ARBs, did not succeed and remained controversial. While many of the antiviral drugs like remdesivir, favipiravir, lopinavir,
ritonavir, oseltamivir could be taken for the clinical trials in various countries, remdesivir could succeed to a great extent as
compared to other drugs. WHO has come up with an initiative known as multi-country ‘Solidarity Trial’ for developing a
potential drug or therapy against COVID-19. However, the most preferred drugs used for repurposing like
hydroxychloroquine and remdesivir have not shown predictable results in solidarity trials.
Conclusions: The analyses of several ongoing and partially concluded clinical trials suggest that drug repurposing can be
one of the major strategies for the treatment of COVID-19. Further, guidelines framed by the WHO through Infection
Prevention and Control for monitoring the widespread of this COVID-19 across the world is another aggressive attempt
finding the solution for the treatment for COVID-19.