Background: Neonatal hyperbilirubinemia is a serious neonatal problem which had hazardous effect in the
neonates when the level of indirect bilirubin is increased to the levels that could cause kernicterus.
Aims: The aim of this research is to study the cord blood levels of erythropoietin (EPO), bilirubin and reticulocyte count
(RC) as early predictors of neonatal hyperbilirubinemia.
Methods: A prospective case control study, which was done at Tanta University Hospital (TUH) from July 2016 to March
2018 on 90 neonates. The studied neonates were divided into 2 groups: Group 1 (45 neonates) who developed pathological
hyperbilirubinemia and required treatment and group 2(45 neonates) who did not develop pathological hyperbilirubinemia
and did not require treatment. Cord blood levels of EPO, bilirubin and RC were measured in all the studied neonates in both
Results: There was significant difference between both groups as regard cord blood bilirubin (CBB), hemoglobin, EPO &
RC levels where the P. value is 0.001*,0.027, *0.001*&0.001*respectively. There was significant positive correlation
between cord Blood EPO levels and both CBB & cord blood RC with r=0.610 & 0.579 respectively and P. value is 0.001*
& 0.001* respectively. As regard to ROC curve ,There was superiority of cord blood EPO levels where the cut off value was
22.5 mIU/ml while the sensitivity & specificity were 96 & 89 respectively then the cord blood RC where the cut off value
was 5.7% while the sensitivity & specificity were 93 & 85 respectively and lastly CBB where the cut off value was 1.8
mg/dl while the sensitivity & specificity were 89 & 78 respectively.
Conclusion: Cord blood levels of EPO, bilirubin and RC were increased in cases of pathological neonatal
Recommendation: Cord blood levels of EPO, bilirubin and RC could be used for early prediction of pathological neonatal