Temperature is a fundamental factor that affects many functions and structural aspects of physiological systems.
Despite its importance, little studies have performed so far for investigating the compartments and mechanisms engaged in
the response of cellular systems to temperature perturbation.
In this review, focusing on stem cells, we tried to perform a literature review for investigating the possible ways that
temperature reduction [hypothermia] affects stem cell function and behavior. Besides, using the obtained results of this
investigation, the possible mechanisms are proposed.
The survey indicates that profound hypothermia enhances cell adhesion by increasing the stability of E-cadherins.
Furthermore, mild hypothermia increases stem cell survival by reducing oxidative stress and prevents apoptosis via the
overexpression of anti-apoptotic heat shock proteins. Mild-hypothermia also promotes cell proliferation by affecting gene
expression in several ways. Even though it seems that hypothermia generally reduced stem cell differentiation, some
inconsistencies are observed between obtained results from the literature.
Based on the obtained results, mechanisms responsible for temperature effect of hypothermia in profound and mild ranges are
given that might help researcher for real experiments.