The phosphorus-containing heterocycles are an important class of compounds in organic chemistry.
Because of their potential application in many fields, especially, the synthetic pesticides, medicine and catalyst,
the phosphorus-containing heterocycles have attracted continuous attention from organic synthesis scientists. The
development of efficient and low-cost catalytic systems is of great interest for the construction of heterocycles
C-P bond. Usually, the phosphorus-containing heterocycles is prepared via direct carbon–hydrogen (C-H) bond
activation or pre-functionalized of heterocycles with phosphorus-hydrogen (P-H) bond of phosphorus compounds
reaction by metal-catalyzed. This review summarizes recent progress in the heterocycles C-P bond formation reactions
by metal-catalyzed, which mainly focus on the discussion of the reaction mechanism. It aims to provide
efficient methods for the future synthesis and application in this field.
Keywords: Phosphorus-containing heterocycles, metal-catalyzed, C-P bond, cross-coupling reaction, C-H bond activation, radical addition.
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