Background: Behçet’s disease (BD) is a rare systemic vasculitis of unknown etiology
with relapsing and remitting course, characterized by triple-symptom complex of recurrent attacks
of oral aphthous ulcers, genital ulcers and ocular lesions and other clinical features that include dermatological,
cardiovascular, gastrointestinal, and neurological manifestations. The main goal of management
is to prevent relapses and suppress inflammation rapidly for major organ involvement
that may cause damage and even be fatal.
Case Presentation: We hereby describe a case of a patient with Behçet’s disease followed in our
rheumatology consultation over the course of 15 years with multi-organ involvement resistant to
several treatments and showed partial results with IL-1 inhibitors, particularly anakinra and canakinumab,
while also discussing the current treatments of refractory BD and how early implementation
of treatments could make a difference.