Potential Epigenetic Targets for Combating Alzheimer’s Disease

Author(s): Dheeraj Pandey, Tiyas Pal, Abha Sharma*, SJS Flora*

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 21 , Issue 12 , 2021

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Graphical Abstract:


Memory remains an obligatory regime of the human brain, and impaired memory causes serious obstacles in our everyday life. Alzheimer’s disease (AD) is one such neurodegenerative disease which mostly affects the elderly population, above the age of 60; marked by cognitive impairment of memory. Besides the known targets of AD against the several etiologies known to date, the zone of epigenetics has recently evolved as an ingenious field in AD. Epigenetic modifications do not affect DNA sequence but only long-term gene expression. Considering the complex multifactorial nature of AD, we herein discuss the various epigenetic targets which might give rise to potential therapeutic approaches. We reviewed the possible epigenetic targets for AD-like HDAC, Sirtuins, glial cells, miRNA and epigenetic modifications like DNA methylation. A deeper insight into these target areas can surely evolve AD diagnosis and therapeutics.

Keywords: Alzheimer’s, sirtuins, glial cell, epigenetics, DNA methylation, HDACs, MiRNA, Dicer.

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Article Details

Year: 2021
Published on: 28 December, 2020
Page: [1527 - 1540]
Pages: 14
DOI: 10.2174/1389557521999201228191427
Price: $65

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