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Current Medical Imaging

Editor-in-Chief

ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Review Article

Recent Imaging Advancements for Lung Metastases in Children with Sarcoma

Author(s): Giancarlo Facchini, Luca Ceccarelli*, Paolo Tomà and Alessandra Bartoloni

Volume 17, Issue 2, 2021

Published on: 28 December, 2020

Page: [236 - 243] Pages: 8

DOI: 10.2174/1573405616666201228125657

Price: $65

Abstract

In children and adolescents affected by musculoskeletal sarcomas (both soft tissue and bone sarcomas), the presence of lung metastases is a frequent complication, that should be known since the patient’s prognosis, as management, and treatment depend on it. During the staging phase, the detection of lung metastases should be sensitive and specific, and it should be carried out by minimizing the radiation exposure. To deal with this problem, imaging has reached important goals in recent years, thanks to the development of cone-beam CT or low-dose computed tomography, with some new iterative reconstruction methods, such as Veo and ASIR. Imaging is also fundamental for the possibility to perform lung biopsies under CT guidance, with less morbidity, less time-consumption, and shorter recovery time, compared to surgical biopsies.Moreover, important results have also been demonstrated in the treatment of lung metastases, due to the improvement of new mini-invasive image-guided percutaneous thermal ablation procedures, which proved to be safe and effective also in young patients.

Keywords: Child, X-ray computed tomography, cone-beam computed tomography, sarcoma, neoplasm metastases, ablation techniques.

Graphical Abstract
[1]
Digesu CS, Wiesel O, Vaporciyan AA, Colson YL. Management of sarcoma metastases to the lung. Surg Oncol Clin N Am 2016; 25(4): 721-33.
[http://dx.doi.org/10.1016/j.soc.2016.05.005] [PMID: 27591495]
[2]
Billingsley KG, Burt ME, Jara E, et al. Pulmonary metastases from soft tissue sarcoma: Analysis of patterns of diseases and postmetastasis survival. Ann Surg 1999; 229(5): 602-10.
[http://dx.doi.org/10.1097/00000658-199905000-00002] [PMID: 10235518]
[3]
Yevich S, Gaspar N, Tselikas L, et al. Percutaneous computed tomography-guided thermal ablation of pulmonary osteosarcoma metastases in children. Ann Surg Oncol 2016; 23(4): 1380-6.
[http://dx.doi.org/10.1245/s10434-015-4988-z] [PMID: 26589502]
[4]
Rasalkar DD, Chu WC, Lee V, Paunipagar BK, Cheng FW, Li CK. Pulmonary metastases in children with osteosarcoma: characteristics and impact on patient survival. Pediatr Radiol 2011; 41(2): 227-36.
[http://dx.doi.org/10.1007/s00247-010-1809-1] [PMID: 20814672]
[5]
Harting MT, Blakely ML. Management of osteosarcoma pulmonary metastases. Semin Pediatr Surg 2006; 15(1): 25-9.
[http://dx.doi.org/10.1053/j.sempedsurg.2005.11.005] [PMID: 16458843]
[6]
Ferrari A, De Salvo GL, Brennan B, et al. Synovial sarcoma in children and adolescents: the European Pediatric Soft Tissue Sarcoma Study Group prospective trial (EpSSG NRSTS 2005). Ann Oncol 2015; 26(3): 567-72.
[http://dx.doi.org/10.1093/annonc/mdu562] [PMID: 25488687]
[7]
Scheer M, Dantonello T, Hallmen E, et al. Primary metastatic synovial sarcoma: Experience of the CWS study group. Pediatr Blood Cancer 2016; 63(7): 1198-206.
[http://dx.doi.org/10.1002/pbc.25973] [PMID: 27003095]
[8]
Bielack SS, Hecker-Nolting S, Blattmann C, Kager L. Advances in the management of osteosarcoma. F1000 Res 2016; 5: 2767.
[http://dx.doi.org/10.12688/f1000research.9465.1] [PMID: 27990273]
[9]
Meyer JS, Nadel HR, Marina N, et al. Imaging guidelines for children with Ewing sarcoma and osteosarcoma: a report from the Children’s Oncology Group Bone Tumor Committee. Pediatr Blood Cancer 2008; 51(2): 163-70.
[http://dx.doi.org/10.1002/pbc.21596] [PMID: 18454470]
[10]
Rothermundt C, Seddon BM, Dileo P, et al. Follow-up practices for high-grade extremity Osteosarcoma. BMC Cancer 2016; 16: 301.
[http://dx.doi.org/10.1186/s12885-016-2333-y] [PMID: 27154292]
[11]
Shikada Y, Yano T, Maruyama R, Takenoyama M, Maehara Y. Effective utilization of chest X-ray for follow-up of metastatic lung tumor due to soft tissue sarcoma. Ann Thorac Cardiovasc Surg 2013; 19(2): 103-6.
[http://dx.doi.org/10.5761/atcs.oa.11.01867] [PMID: 22971713]
[12]
Davis SD. CT evaluation for pulmonary metastases in patients with extrathoracic malignancy. Radiology 1991; 180(1): 1-12.
[http://dx.doi.org/10.1148/radiology.180.1.2052672] [PMID: 2052672]
[13]
Puri A, Gulia A, Hawaldar R, Ranganathan P, Badwe RA. Does intensity of surveillance affect survival after surgery for sarcomas? Results of a randomized noninferiority trial. Clin Orthop Relat Res 2014; 472(5): 1568-75.
[http://dx.doi.org/10.1007/s11999-013-3385-9] [PMID: 24249538]
[14]
Chang AE, Schaner EG, Conkle DM, Flye MW, Doppman JL, Rosenberg SA. Evaluation of computed tomography in the detection of pulmonary metastases: a prospective study. Cancer 1979; 43(3): 913-6.
[http://dx.doi.org/10.1002/1097-0142(197903)43:3 <913::AID-CNCR2820430319> 3.0.CO;2-Q] [PMID: 284842]
[15]
Kane JM III. Surveillance strategies for patients following surgical resection of soft tissue sarcomas. Curr Opin Oncol 2004; 16(4): 328-32.
[http://dx.doi.org/10.1097/01.cco.0000127879.62254.d3] [PMID: 15187887]
[16]
Lord HK, Salter DM, MacDougall RH, Kerr GR. Is routine chest radiography a useful test in the follow up of all adult patients with soft tissue sarcoma? Br J Radiol 2006; 79(946): 799-800.
[http://dx.doi.org/10.1259/bjr/69175634] [PMID: 16728411]
[17]
García Franco CE, Torre W, Tamura A, et al. Long-term results after resection for bone sarcoma pulmonary metastases. Eur J Cardiothorac Surg 2010; 37(5): 1205-8.
[http://dx.doi.org/10.1016/j.ejcts.2009.11.026] [PMID: 20022760]
[18]
Papagelopoulos PJ, Galanis EC, Vlastou C, et al. Current concepts in the evaluation and treatment of osteosarcoma. Orthopedics 2000; 23(8): 858-67.
[PMID: 10952054]
[19]
Fahimi J, Herring A, Harries A, Gonzales R, Alter H. Computed tomography use among children presenting to emergency departments with abdominal pain. Pediatrics 2012; 130(5): e1069-75.
[http://dx.doi.org/10.1542/peds.2012-0739] [PMID: 23045569]
[20]
Macias CG, Sahouria JJ. The appropriate use of CT: quality improvement and clinical decision-making in pediatric emergency medicine. Pediatr Radiol 2011; 41(Suppl.2): 498-504.
[http://dx.doi.org/10.1007/s00247-011-2102-7] [PMID: 21847729]
[21]
Menoch MJ, Hirsh DA, Khan NS, Simon HK, Sturm JJ. Trends in computed tomography utilization in the pediatric emergency department. Pediatrics 2012; 129(3): e690-7.
[http://dx.doi.org/10.1542/peds.2011-2548] [PMID: 22331345]
[22]
Moreno MA. Advice for patients. Decreasing unnecessary radiation exposure for children. Arch Pediatr Adolesc Med 2011; 165(5): 480.
[http://dx.doi.org/10.1001/archpediatrics.2011.59] [PMID: 21536966]
[23]
Nishida J, Kitagawa K, Nagata M, Yamazaki A, Nagasawa N, Sakuma H. Model-based iterative reconstruction for multi-detector row CT assessment of the Adamkiewicz artery. Radiology 2014; 270(1): 282-91.
[http://dx.doi.org/10.1148/radiol.13122019] [PMID: 23962418]
[24]
Pickhardt PJ, Lubner MG, Kim DH, et al. Abdominal CT with model-based iterative reconstruction (MBIR): Initial results of a prospective trial comparing ultralow-dose with standard-dose imaging. AJR Am J Roentgenol 2012; 199(6): 1266-74.
[http://dx.doi.org/10.2214/AJR.12.9382] [PMID: 23169718]
[25]
Deák Z, Grimm JM, Treitl M, et al. Filtered back projection, adaptive statistical iterative reconstruction, and a model-based iterative reconstruction in abdominal CT: An experimental clinical study. Radiology 2013; 266(1): 197-206.
[http://dx.doi.org/10.1148/radiol.12112707] [PMID: 23169793]
[26]
Silva AC, Lawder HJ, Hara A, Kujak J, Pavlicek W. Innovations in CT dose reduction strategy: application of the adaptive statistical iterative reconstruction algorithm. AJR Am J Roentgenol 2010; 194(1): 191-9.
[http://dx.doi.org/10.2214/AJR.09.2953] [PMID: 20028923]
[27]
Shin HO, Falck CV, Galanski M. Low-contrast detectability in volume rendering: a phantom study on multidetector-row spiral CT data. Eur Radiol 2004; 14(2): 341-9.
[http://dx.doi.org/10.1007/s00330-003-2084-4] [PMID: 14556033]
[28]
Haggerty JE, Smith EA, Kunisaki SM, Dillman JR. CT imaging of congenital lung lesions: Effect of iterative reconstruction on diagnostic performance and radiation dose. Pediatr Radiol 2015; 45(7): 989-97.
[http://dx.doi.org/10.1007/s00247-015-3281-4] [PMID: 25636530]
[29]
Sun J, Zhang Q, Hu D, Duan X, Peng Y. Improving pulmonary vessel image quality with a full model-based iterative reconstruction algorithm in 80kVp low-dose chest CT for pediatric patients aged 0-6 years. Acta Radiol 2015; 56(6): 761-8.
[http://dx.doi.org/10.1177/0284185114540884] [PMID: 25246093]
[30]
Smith EA, Dillman JR, Goodsitt MM, Christodoulou EG, Keshavarzi N, Strouse PJ. Model-based iterative reconstruction: effect on patient radiation dose and image quality in pediatric body CT. Radiology 2014; 270(2): 526-34.
[http://dx.doi.org/10.1148/radiol.13130362] [PMID: 24091359]
[31]
Koc G, Courtier JL, Phelps A, Marcovici PA, MacKenzie JD. Computed tomography depiction of small pediatric vessels with model-based iterative reconstruction. Pediatr Radiol 2014; 44(7): 787-94.
[http://dx.doi.org/10.1007/s00247-014-2899-y] [PMID: 24531191]
[32]
Miéville FA, Berteloot L, Grandjean A, et al. Model-based iterative reconstruction in pediatric chest CT: assessment of image quality in a prospective study of children with cystic fibrosis. Pediatr Radiol 2013; 43(5): 558-67.
[http://dx.doi.org/10.1007/s00247-012-2554-4] [PMID: 23224105]
[33]
Neroladaki A, Botsikas D, Boudabbous S, Becker CD, Montet X. Computed tomography of the chest with model-based iterative reconstruction using a radiation exposure similar to chest X-ray examination: preliminary observations. Eur Radiol 2013; 23(2): 360-6.
[http://dx.doi.org/10.1007/s00330-012-2627-7] [PMID: 22892722]
[34]
Kim HJ, Yoo SY, Jeon TY, Kim JH. Model-based iterative reconstruction in ultra-low-dose pediatric chest CT: Comparison with adaptive statistical iterative reconstruction. Clin Imaging 2016; 40(5): 1018-22.
[http://dx.doi.org/10.1016/j.clinimag.2016.06.006] [PMID: 27348057]
[35]
Rosenfield NS, Keller MS, Markowitz RI, Touloukian R, Seashore J. CT differentiation of benign and malignant lung nodules in children. J Pediatr Surg 1992; 27(4): 459-61.
[http://dx.doi.org/10.1016/0022-3468(92)90336-6] [PMID: 1522456]
[36]
Silva CT, Amaral JG, Moineddin R, Doda W, Babyn PS. CT characteristics of lung nodules present at diagnosis of extrapulmonary malignancy in children. AJR Am J Roentgenol 2010; 194(3): 772-8.
[http://dx.doi.org/10.2214/AJR.09.2490] [PMID: 20173158]
[37]
EURO-E.W.I.N.G. 99 EUROpean Ewing tumour Working Initiative of National Groups Ewing Tumour Studies 1999 EE 99 Amended Version. 2006 .https://www.skion.nl/workspace/uploads/ee99_amended_treo__2006_02_14.pdf
[38]
ESMO / European Sarcoma Network Working Group. Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2012; 23(Suppl. 7): vii100-9.
[http://dx.doi.org/10.1093/annonc/mds254] [PMID: 22997441]
[39]
Olsen ØE. Why measure tumours? Pediatr Radiol 2015; 45(1): 35-41.
[http://dx.doi.org/10.1007/s00247-014-3148-0] [PMID: 25552390]
[40]
London K, Stege C, Cross S, et al. 18F-FDG PET/CT compared to conventional imaging modalities in pediatric primary bone tumors. Pediatr Radiol 2012; 42(4): 418-30.
[http://dx.doi.org/10.1007/s00247-011-2278-x] [PMID: 22134535]
[41]
Quartuccio N, Fox J, Kuk D, et al. Pediatric bone sarcoma: Diagnostic performance of ¹-;F-FDG PET/CT versus conventional imaging for initial staging and follow-up. AJR Am J Roentgenol 2015; 204(1): 153-60.
[http://dx.doi.org/10.2214/AJR.14.12932] [PMID: 25539251]
[42]
Franzius C, Daldrup-Link HE, Sciuk J, et al. FDG-PET for detection of pulmonary metastases from malignant primary bone tumors: Comparison with spiral CT. Ann Oncol 2001; 12(4): 479-86.
[http://dx.doi.org/10.1023/A:1011111322376] [PMID: 11398879]
[43]
Christensen JA, Nathan MA, Mullan BP, Hartman TE, Swensen SJ, Lowe VJ. Characterization of the solitary pulmonary nodule: 18F-FDG PET versus nodule-enhancement CT. AJR Am J Roentgenol 2006; 187(5): 1361-7.
[http://dx.doi.org/10.2214/AJR.05.1166] [PMID: 17056930]
[44]
Galluzzo A, Genova C, Dioguardi S, Midiri M, Cajozzo M. Current role of computed tomography-guided transthoracic needle biopsy of metastatic lung lesions. Future Oncol 2015; 11(Suppl. 2): 43-6.
[http://dx.doi.org/10.2217/fon.14.258] [PMID: 25662328]
[45]
Connolly BL, Chait PG, Duncan DS, Taylor G. CT-guided percutaneous needle biopsy of small lung nodules in children. Pediatr Radiol 1999; 29(5): 342-6.
[http://dx.doi.org/10.1007/s002470050603] [PMID: 10382211]
[46]
Cahill AM, Baskin KM, Kaye RD, Fitz CR, Towbin RB. CT-guided percutaneous lung biopsy in children. J Vasc Interv Radiol 2004; 15(9): 955-60.
[http://dx.doi.org/10.1097/01.RVI.0000130814.63277.F2] [PMID: 15361563]
[47]
Heerink WJ, de Bock GH, de Jonge GJ, Groen HJ, Vliegenthart R, Oudkerk M. Complication rates of CT-guided transthoracic lung biopsy: meta-analysis. Eur Radiol 2017; 27(1): 138-48.
[http://dx.doi.org/10.1007/s00330-016-4357-8] [PMID: 27108299]
[48]
Shivaram GM, Gill AE, Monroe EJ, Koo KSH, Hawkins CM. Cone-beam computed tomography guidance with navigational overlay for percutaneous lung nodule biopsy. Pediatr Radiol 2019; 49(3): 327-31.
[http://dx.doi.org/10.1007/s00247-018-4296-4] [PMID: 30411171]
[49]
Wilkinson AG, Paton JY, Gibson N, Howatson AG. CT-guided 14-G cutting needle lung biopsy in children: Safe and effective. Pediatr Radiol 1999; 29(7): 514-6.
[http://dx.doi.org/10.1007/s002470050633] [PMID: 10398786]
[50]
Acord M, Shellikeri S, Vatsky S, et al. Reduced-dose C-arm computed tomography applications at a pediatric institution. Pediatr Radiol 2017; 47(13): 1817-24.
[http://dx.doi.org/10.1007/s00247-017-3964-0] [PMID: 28983677]
[51]
Lee WJ, Chong S, Seo JS, Shim HJ. Transthoracic fine-needle aspiration biopsy of the lungs using a C-arm cone-beam CT system: diagnostic accuracy and post-procedural complications. Br J Radiol 2012; 85(1014): e217-22.
[http://dx.doi.org/10.1259/bjr/64727750] [PMID: 22010033]
[52]
Choo JY, Park CM, Lee NK, Lee SM, Lee HJ, Goo JM. Percutaneous transthoracic needle biopsy of small (≤ 1 cm) lung nodules under C-arm cone-beam CT virtual navigation guidance. Eur Radiol 2013; 23(3): 712-9.
[http://dx.doi.org/10.1007/s00330-012-2644-6] [PMID: 22976917]
[53]
de Baere T, Tselikas L, Gravel G, et al. Interventional radiology: Role in the treatment of sarcomas. Eur J Cancer 2018; 94: 148-55.
[http://dx.doi.org/10.1016/j.ejca.2018.02.017] [PMID: 29567631]
[54]
ESMO/European Sarcoma Network Working Group. Soft tissue and visceral sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2014; 25(Suppl. 3)(): iii102-12.
[http://dx.doi.org/10.1093/annonc/mdu254] [PMID: 25210080]
[55]
Grilley-Olson JE, Webber NP, Demos DS, Christensen JD, Kirsch DG. Multidisciplinary management of oligometastatic soft tissue sarcoma. Am Soc Clin Oncol Educ Book 2018; 38: 939-48.
[http://dx.doi.org/10.1200/EDBK_200573] [PMID: 30231386]
[56]
von Mehren M, Randall RL, Benjamin RS, et al. Soft tissue sarcoma, version 2.2016, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw 2016; 14(6): 758-86.
[http://dx.doi.org/10.6004/jnccn.2016.0078] [PMID: 27283169]
[57]
Gow KW, Saad DF, Koontz C, Wulkan ML. Minimally invasive thoracoscopic ultrasound for localization of pulmonary nodules in children. J Pediatr Surg 2008; 43(12): 2315-22.
[http://dx.doi.org/10.1016/j.jpedsurg.2008.08.031] [PMID: 19040964]
[58]
Bax NM. Laparoscopic surgery in infants and children. Eur J Pediatr Surg 2005; 15(5): 319-24.
[http://dx.doi.org/10.1055/s-2005-865809] [PMID: 16254843]
[59]
Suzuki K, Nagai K, Yoshida J, et al. Video-assisted thoracoscopic surgery for small indeterminate pulmonary nodules: Indications for preoperative marking. Chest 1999; 115(2): 563-8.
[http://dx.doi.org/10.1378/chest.115.2.563] [PMID: 10027460]
[60]
Watanabe K, Nomori H, Ohtsuka T, Kaji M, Naruke T, Suemasu K. Usefulness and complications of computed tomography-guided lipiodol marking for fluoroscopy-assisted thoracoscopic resection of small pulmonary nodules: experience with 174 nodules. J Thorac Cardiovasc Surg 2006; 132(2): 320-4.
[http://dx.doi.org/10.1016/j.jtcvs.2006.04.012] [PMID: 16872957]
[61]
Partrick DA, Bensard DD, Teitelbaum DH, Geiger JD, Strouse P, Harned RK. Successful thoracoscopic lung biopsy in children utilizing preoperative CT-guided localization. J Pediatr Surg 2002; 37(7): 970-3.
[http://dx.doi.org/10.1053/jpsu.2002.33820] [PMID: 12077751]
[62]
Carter JJ, Whelan RL. The immunologic consequences of laparoscopy in oncology. Surg Oncol Clin N Am 2001; 10(3): 655-77.
[http://dx.doi.org/10.1016/S1055-3207(18)30056-5] [PMID: 11685934]
[63]
Sylla P, Kirman I, Whelan RL. Immunological advantages of advanced laparoscopy. Surg Clin North Am 2005; 85(1): 1-18, vii.
[http://dx.doi.org/10.1016/j.suc.2004.09.005] [PMID: 15619524]
[64]
Saenz NC, Conlon KC, Aronson DC, LaQuaglia MP. The application of minimal access procedures in infants, children, and young adults with pediatric malignancies. J Laparoendosc Adv Surg Tech A 1997; 7(5): 289-94.
[http://dx.doi.org/10.1089/lap.1997.7.289] [PMID: 9453873]
[65]
Gronchi A, Guadagnolo BA, Erinjeri JP. Local ablative therapies to metastatic soft tissue sarcoma. Am Soc Clin Oncol Educ Book 2016; 35: e566-75.
[http://dx.doi.org/10.1200/EDBK_157450] [PMID: 27249769]
[66]
de Baère T, Aupérin A, Deschamps F, et al. Radiofrequency ablation is a valid treatment option for lung metastases: experience in 566 patients with 1037 metastases. Ann Oncol 2015; 26(5): 987-91.
[http://dx.doi.org/10.1093/annonc/mdv037] [PMID: 25688058]
[67]
Nakamura T, Matsumine A, Yamakado K, et al. Lung radiofrequency ablation in patients with pulmonary metastases from musculoskeletal sarcomas [corrected]. Cancer 2009; 115(16): 3774-81.
[http://dx.doi.org/10.1002/cncr.24420] [PMID: 19514086]
[68]
Saumet L, Deschamps F, Marec-Berard P, et al. Radiofrequency ablation of metastases from osteosarcoma in patients under 25 years: the SCFE experience. Pediatr Hematol Oncol 2015; 32(1): 41-9.
[http://dx.doi.org/10.3109/08880018.2014.926469] [PMID: 25007012]
[69]
Palussière J, Italiano A, Descat E, et al. Sarcoma lung metastases treated with percutaneous radiofrequency ablation: results from 29 patients. Ann Surg Oncol 2011; 18(13): 3771-7.
[http://dx.doi.org/10.1245/s10434-011-1806-0] [PMID: 21638099]
[70]
Sato T, Iguchi T, Hiraki T, et al. Radiofrequency ablation of pulmonary metastases from sarcoma: Single-center retrospective evaluation of 46 patients. Jpn J Radiol 2017; 35(2): 61-7.
[http://dx.doi.org/10.1007/s11604-016-0601-z] [PMID: 27864664]

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