A Review on Screening Models for Potential Therapeutic Candidates and Targets Against SARS-CoV-2

Author(s): Mohana Das, Manish Kumar, Abhishek Jha, D.R. Madhukiran, Kanchan Bharti, Shomedeep Mondal, Brahmeshwar Mishra*

Journal Name: Current Drug Targets

Volume 22 , Issue 11 , 2021


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Abstract:

Coronaviruses are a group of known RNA virus which primarily infect the respiratory tract, and also neurological, enteric, and hepatic systems. Endemic outbreaks of Middle East Coronavirus Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) have been observed in recent decades. A new strain named the SARS CoV-2(- COVID-19) virus has now spread across the globe. SARS-CoV-2 is highly communicable and has culminated in a massive pandemic of COVID-19. Currently, no successful treatment is available. Therefore, an urgent need is there for new screening models that can aid in identifying the drugs with potential activity against COVID-19. The current review aims to discuss various in-silico, in- -vitro and in-vivo screening methods that can potentially be used to expedite the discovery of new active therapeutic candidates and vaccines, drug targets, and repurposing the commercially available drugs against COVID-19 for the effective management of the infection and thereby controlling this pandemic. Further, the current status of drugs and vaccines under clinical investigation has been summarized.

Keywords: Corona Virus, COVID-19, Screening Models, SARS-CoV, enteric, Middle East Coronavirus Respiratory Syndrome (MERS-CoV).

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Article Details

VOLUME: 22
ISSUE: 11
Year: 2021
Published on: 28 December, 2020
Page: [1232 - 1254]
Pages: 23
DOI: 10.2174/1389450121666201228122845
Price: $65

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