Coronaviruses are a group of known RNA virus which primarily infect the respiratory
tract, and also neurological, enteric, and hepatic systems. Endemic outbreaks of Middle East Coronavirus
Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome Coronavirus
(SARS-CoV) have been observed in recent decades. A new strain named the SARS CoV-2(-
COVID-19) virus has now spread across the globe. SARS-CoV-2 is highly communicable and has
culminated in a massive pandemic of COVID-19. Currently, no successful treatment is available.
Therefore, an urgent need is there for new screening models that can aid in identifying the drugs
with potential activity against COVID-19. The current review aims to discuss various in-silico, in-
-vitro and in-vivo screening methods that can potentially be used to expedite the discovery of new
active therapeutic candidates and vaccines, drug targets, and repurposing the commercially available
drugs against COVID-19 for the effective management of the infection and thereby controlling
this pandemic. Further, the current status of drugs and vaccines under clinical investigation
has been summarized.