Efficacy of Topical Formulations in Healing of Caesarean Scars Using Non-Invasive Devices: A Controlled Trial

(E-pub Ahead of Print)

Author(s): Alia Abdullah, Rawya Al Kredly, Mohamed Baguneid*

Journal Name: Applied Drug Research, Clinical Trials and Regulatory Affairs
(Formerly Applied Clinical Research, Clinical Trials and Regulatory Affairs)


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Abstract:

Background: Despite the availability of many topical formulations for scar treatment, an objective evaluation of their effect is lacking.

Objective: To assess the physiological, structural, and mechanical parameters of scar healing by a scar ointment (MEBOScar).

Methods: 45 patients from the Department of Obstetrics at Al Ain Hospital, UAE, with recently acquired Pfannenstiel scars were recruited into this prospective, open-label, controlled study. Scar ointment was applied to a lateral third of the scar; positive control (silicone gel based topical) to the other lateral third; the middle third was left untreated (negative control). The scars were evaluated at 4 time points up to 12 weeks using non-invasive devices and a scar questionnaire.

Results: In comparison with silicone gel, there was a significant reduction in trans epithelial water loss at weeks 2,4,8, and 12 (p<0.001) and scar area at weeks 4, 8 and 12 (p<0.001) with scar ointment. The skin elasticity at week 4 was significantly increased by scar ointment (p=0.007). By week 12, gross colour mismatch of the scar was described by 9% patients with scar ointment (24% with silicone gel, 42% with no treatment; p<0.001). There was significant improvement in scar texture with scar ointment by week 12 (p<0.001).

Conclusions: Scar ointment has beneficial effects on objective and subjective patient-reported parameters of Pfannenstiel scars.

Keywords: Scar treatment; MEBO-Scar ointment; patient reported outcomes; Dermalab; Manchester scar scale

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Article Details

Published on: 27 December, 2020
(E-pub Ahead of Print)
DOI: 10.2174/2213476X07999201228111027
Price: $95

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