Background: Modified electrodes have advanced from the initial studies aimed at understanding
electron transfer in films to applications in areas such as energy production and analytical
chemistry. This review emphasizes the major classes of modified electrodes with mediators
that are being explored for improving analytical methodology. Chemically modified electrodes
(CMEs) have been widely used to counter the problems of poor sensitivity and selectivity faced in
bare electrodes. We have briefly reviewed the organometallic and organic mediators that have been
extensively employed to engineer adapted electrode surfaces for the detection of different compounds.
Also, the characteristics of the materials that improve the electrocatalytic activity of the
modified surfaces are discussed.
Objective: Improvement and promotion of pragmatic CMEs have generated a diversity of novel
and probable strong detection prospects for electroanalysis. While the capability of handling the
chemical nature of the electrode/solution interface accurately and creatively increases , it is predictable
that different mediators-based CMEs could be developed with electrocatalytic activity and
completely new applications be advanced.