Nanosuspensions - An Update on Recent Patents, Methods of Preparation, and Evaluation Parameters

Author(s): Harpreet K. Khanuja, Rajendra Awasthi, Meenu Mehta, Saurabh Satija, Alaa A.A. Aljabali, Murtaza M. Tambuwala, Dinesh K. Chellappan, Kamal Dua, Harish Dureja*

Journal Name: Recent Patents on Nanotechnology

Volume 15 , Issue 4 , 2021

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Graphical Abstract:


Background: Nanosuspensions are colloidal systems consisting of pure drug and stabilizers, without matrix or lyophilized into a solid matrix. Nanosuspensions improve the solubility of the drug both in the aqueous and organic phases. Nanosuspensions are also known as brick dust molecules, as they increase the dissolution of a system and improve absorption.

Methods: Extensive information related to nanosuspensions and its associated patents were collected using Pub Med and Google Scholar.

Results: Over the last decade nanosuspensions have attracted tremendous interest in pharmaceutical research. It provides unique features including, improved solubility, high drug loading capacity, and passive targeting. These particles are cost-effective, simple, and have lesser side effects with minimal dose requirements. However, the stability of nanosuspensions still warrants attention.

Conclusion: Nanosuspensions play a vital role in handling the numerous drug entities with difficult physico-chemical characteristics such as solubility and can further aid with a range of routes that include nasal, transdermal, ocular, parenteral, pulmonary etc. This review highlights the relevance of nanosuspensions in achieving safe, effective and targeted drug delivery.

Keywords: Nanosuspension, colloidal, stability, spin coating, high-pressure homogenization, dissolution rate.

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Article Details

Year: 2021
Published on: 23 December, 2020
Page: [351 - 366]
Pages: 16
DOI: 10.2174/1872210514666201224103010
Price: $65

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