Fluorine in Drug Discovery
Pp. 209-227 (19)
Marcus Vinícius Nora de Souza
Fluorine chemistry is an important area that made a significant impact on
drug discovery development, which can be seen by a large number of drugs in the
market containing this chemical element. The success of drugs containing fluorine
atoms in its structures is due to its chemical properties compared to the other elements,
providing several advantages in drug discovery. Some of these advantages are better
metabolic stability, avoiding undesired metabolizations, and improving the
bioavailability of the drugs, among others. Due to its importance in drug discovery, the
exercises below are focused on fluorine chemistry.
Bioactive compounds, Catalyst, Chemical transformations,
Combinatorial chemistry, Drugs, Exercises, Fluorine, Heteroaromatic compounds,
Medicinal chemistry, Molecules, Reaction conditions, Reagents, Retrosynthetic
analysis, Substances, Synthesis, Synthons.
FioCruz-Fundação Oswaldo Cruz Rio de Janeiro - RJ, 21040-900, Brazil.