Exercises in Organic Synthesis Based on Synthetic Drugs

Exercises in Organic Synthesis Based on Synthetic Drugs

Exercises in Organic Synthesis Based on Synthetic Drugs presents information on topics about the synthesis of biologically active compounds which are used against a range of diseases in both humans ...
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Click Chemistry

Pp. 197-208 (12)

Marcus Vinícius Nora de Souza

Abstract

The most famous reaction, based on the click chemistry concept, is to obtain 1,2,3-triazoles, employing the 1,3-dipolar cycloaddition reaction between azides and alkynes. This reaction raised intense interest in academics and industrialists and was discovered independently by Sharpless and the Danish Morten Meldal in the year 2002. They demonstrated that the addition of copper as a catalyst has several advantages, such as an increase in the speed of the reaction, regioselectivity, high yields, and reactions are easy to elaborate. Due to its importance in drug discovery, the exercises below are based on this concept.

Keywords:

1, 2, 3-triazoles, Alkynes, Azides, Bioactive compounds, Catalyst, Chemical transformations, Click chemistry, Combinatorial chemistry, Copper, Drugs, Exercises, Heteroaromatic compounds, Medicinal chemistry, Molecules, Reaction conditions, Reagents, Retrosynthetic analysis, Substances, Synthesis, Synthons, 1, 3-dipolar cycloaddition.

Affiliation:

FioCruz-Fundação Oswaldo Cruz Rio de Janeiro - RJ, 21040-900, Brazil.