Pp. 197-208 (12)
Marcus Vinícius Nora de Souza
The most famous reaction, based on the click chemistry concept, is to obtain
1,2,3-triazoles, employing the 1,3-dipolar cycloaddition reaction between azides and
alkynes. This reaction raised intense interest in academics and industrialists and was
discovered independently by Sharpless and the Danish Morten Meldal in the year 2002.
They demonstrated that the addition of copper as a catalyst has several advantages,
such as an increase in the speed of the reaction, regioselectivity, high yields, and
reactions are easy to elaborate. Due to its importance in drug discovery, the exercises
below are based on this concept.
1, 2, 3-triazoles, Alkynes, Azides, Bioactive compounds, Catalyst,
Chemical transformations, Click chemistry, Combinatorial chemistry, Copper,
Drugs, Exercises, Heteroaromatic compounds, Medicinal chemistry, Molecules,
Reaction conditions, Reagents, Retrosynthetic analysis, Substances, Synthesis,
Synthons, 1, 3-dipolar cycloaddition.
FioCruz-Fundação Oswaldo Cruz Rio de Janeiro - RJ, 21040-900, Brazil.