Multicomponent Reaction (MCR)
Pp. 176-196 (21)
Marcus Vinícius Nora de Souza
Abstract
Multicomponent reaction (MCR) is a type of reaction based on a mixture of
three or more compounds or reagents leading only to one or a major molecule being
able to form complex molecules with a high degree of control of the stereogenic
centers in only one step. This methodology is also a useful tool in medicinal chemistry
to produce a diversity of compounds for biological evaluation. Due to its importance,
the exercises below focus on this technique.
Keywords:
Bioactive compounds, Chemical transformations, Combinatorial
chemistry, Drugs, Exercises, Heteroaromatic compounds, Medicinal chemistry,
Molecules, Multicomponent reaction (MCR), Reaction conditions, Reagents,
Retrosynthetic analysis, Substances, Synthesis, Synthons.
Affiliation:
FioCruz-Fundação Oswaldo Cruz Rio de Janeiro - RJ, 21040-900, Brazil.