Exercises in Organic Synthesis Based on Synthetic Drugs

Exercises in Organic Synthesis Based on Synthetic Drugs

Exercises in Organic Synthesis Based on Synthetic Drugs presents information on topics about the synthesis of biologically active compounds which are used against a range of diseases in both humans ...
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Multicomponent Reaction (MCR)

Pp. 176-196 (21)

Marcus Vinícius Nora de Souza

Abstract

Multicomponent reaction (MCR) is a type of reaction based on a mixture of three or more compounds or reagents leading only to one or a major molecule being able to form complex molecules with a high degree of control of the stereogenic centers in only one step. This methodology is also a useful tool in medicinal chemistry to produce a diversity of compounds for biological evaluation. Due to its importance, the exercises below focus on this technique.

Keywords:

Bioactive compounds, Chemical transformations, Combinatorial chemistry, Drugs, Exercises, Heteroaromatic compounds, Medicinal chemistry, Molecules, Multicomponent reaction (MCR), Reaction conditions, Reagents, Retrosynthetic analysis, Substances, Synthesis, Synthons.

Affiliation:

FioCruz-Fundação Oswaldo Cruz Rio de Janeiro - RJ, 21040-900, Brazil.