Exercises in Organic Synthesis Based on Synthetic Drugs

Exercises in Organic Synthesis Based on Synthetic Drugs

Exercises in Organic Synthesis Based on Synthetic Drugs presents information on topics about the synthesis of biologically active compounds which are used against a range of diseases in both humans ...
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Combinatorial Chemistry

Pp. 165-175 (11)

Marcus Vinícius Nora de Souza

Abstract

Combinatorial chemistry is a methodology developed based on the synthesis of many compounds (hundreds, thousands, or even millions) in a simple chemical process building libraries of these compounds. In medicinal chemistry, an essential factor is the number of different molecules to be produced. For obtaining a leading compound and later a candidate drug, the biological evaluation of thousands of compounds is necessary. Therefore, the exercises below are based on combinatorial chemistry.

Keywords:

Bioactive compounds, Combinatorial chemistry, Chemical transformations, Drugs, Exercises, Heteroaromatic compounds, Medicinal chemistry, Molecules, Reaction conditions, Reagents, Retrosynthetic analysis, Substances, Synthesis, Synthons.

Affiliation:

FioCruz-Fundação Oswaldo Cruz Rio de Janeiro - RJ, 21040-900, Brazil.