Pp. 165-175 (11)
Marcus Vinícius Nora de Souza
Combinatorial chemistry is a methodology developed based on the synthesis
of many compounds (hundreds, thousands, or even millions) in a simple chemical
process building libraries of these compounds. In medicinal chemistry, an essential
factor is the number of different molecules to be produced. For obtaining a leading
compound and later a candidate drug, the biological evaluation of thousands of
compounds is necessary. Therefore, the exercises below are based on combinatorial
Bioactive compounds, Combinatorial chemistry, Chemical
transformations, Drugs, Exercises, Heteroaromatic compounds, Medicinal
chemistry, Molecules, Reaction conditions, Reagents, Retrosynthetic analysis,
Substances, Synthesis, Synthons.
FioCruz-Fundação Oswaldo Cruz Rio de Janeiro - RJ, 21040-900, Brazil.