Exercises in Organic Synthesis Based on Synthetic Drugs

Exercises in Organic Synthesis Based on Synthetic Drugs

Exercises in Organic Synthesis Based on Synthetic Drugs presents information on topics about the synthesis of biologically active compounds which are used against a range of diseases in both humans ...
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Nitriles

Pp. 150-164 (15)

Marcus Vinícius Nora de Souza

Abstract

Nitrile is a chemical function found in several drugs in the market for different kinds of diseases and can be transformed into several other functional groups such as ketones, aldehydes, carboxylic acids, amines, amides, and other functional groups. The use of nitriles is also advantageous in forming heteroaromatic nuclei with important applications in medicinal chemistry. In this chapter, the exercises are based on the use of nitriles to form a different nucleus.

Keywords:

Bioactive compounds, Chemical transformations, Drugs, Exercises, Heteroaromatic compounds, Hydrazine, Medicinal chemistry, Molecules, Nitriles, Reaction conditions, Reagents, Retrosynthetic analysis, Substances, Synthesis, Synthons.

Affiliation:

FioCruz-Fundação Oswaldo Cruz Rio de Janeiro - RJ, 21040-900, Brazil.