Exercises in Organic Synthesis Based on Synthetic Drugs

Exercises in Organic Synthesis Based on Synthetic Drugs

Exercises in Organic Synthesis Based on Synthetic Drugs presents information on topics about the synthesis of biologically active compounds which are used against a range of diseases in both humans ...
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Identifying Drug Structure and Completing the Gaps

Pp. 70-113 (44)

Marcus Vinícius Nora de Souza

Abstract

In this chapter, the exercises below are also based on two themes. The first has an objective of the identification of the structure of the drugs having information of the starting materials and reagents used. This activity also enables the reader to become familiar with different classical chemical transformations used in medicinal chemistry and with varying types of reagents, reaction conditions, and necessary intermediates. In the second theme, the exercises are based on a series of gaps in the synthesis of different drugs. Therefore, it is up to the reader to complete them. This type of exercise is a combination of the themes previously presented. It is necessary to identify the reagents' use, the reaction conditions employed, and the intermediates formed, besides the use of the concept of retrosynthesis.

Keywords:

Bioactive compounds, Chemical transformations, Drugs, Exercises, Medicinal chemistry, Molecules, Reaction conditions, Reagents, Retrosynthetic analysis, Substances, Synthesis, Synthons.

Affiliation:

FioCruz-Fundação Oswaldo Cruz Rio de Janeiro - RJ, 21040-900, Brazil.