How to Build a Drug: Exercises Based on the Concept of Retrosynthetic Analysis
Pp. 1-46 (46)
Marcus Vinícius Nora de Souza
Concepts involving retrosynthesis were and are essential to the development
of organic synthesis as science and art. Therefore, the first four exercises are based on
this concept. These exercises were subdivided into themes and degrees of increasing
difficulty so that the reader could gradually progress and become familiar with their
concepts. Thus, the first exercise begins with the retrosynthetic analysis of drugs based
on the identification of only two synthons and their respective synthetic equivalents
(reagents and substances) necessary for their synthesis. Exercises 2, 3, and 4 are
thematic and based on the identification of epoxides, piperazines, and aldehydes, used
in the synthesis of drugs and bioactive substances as well as other synthons and their
respective synthetic equivalents present in the exercises.
Aldehydes, Drugs, Epoxides, Exercises, Medicinal chemistry,
Organic synthesis, Piperazines, Reagentes, Retrosynthetic analysis, Substances,
FioCruz-Fundação Oswaldo Cruz Rio de Janeiro - RJ, 21040-900, Brazil.