Polyphenols as Potential Therapeutics for Pain and Inflammation in Spinal Cord Injury

(E-pub Ahead of Print)

Author(s): Ashif Iqubal, Musheer Ahmed, Mohammad Kashif Iqubal, Faheem Hyder Pottoo, Syed Ehtaishamul Haque*

Journal Name: Current Molecular Pharmacology


Become EABM
Become Reviewer
Call for Editor

Abstract:

Spinal cord injury (SCI) and associated pain and inflammation caused by the trauma or infection is one of the serious health care issues world-wide. The various inflammatory, redox-sensitive and apoptotic events are contributing factor but altered neuronal function, axonal degeneration, activated microglia, endothelial cells, astrocytes, fibroblasts,pericytes, Schwann cells, meningeal cells are the major player in its pathogenesis. Further, monocytes and neutrophil infiltration get recruited and facilitate the release of chemokines, cytokines, and other mediators of inflammation. This event leads to the production of different amino acids, neuropeptides kinin, prostaglandins, prostacyclin, thromboxane, leukotrienes, bradykinin, histamine, matrix metal proteinases and serotonin that stimulate nerve endings and manifests the inflammation and pain processes, etc. Arachidonic acid (AA), NF-kB, NLRP3 inflammasome, and nitric oxide pathways along with P2X7 receptor and ion channel transient receptor potential (TRP) vanilloid are some of the recently explored targets for modulation of pain and inflammation in SCI. Till now, NSAIDs, opioids, antidepressants, anticonvulsants, NMDA antagonists, α2-adrenergic agonists, and GABA-receptor agonists are used for the management of these pathological conditions. However, these drugs are associated with various side effects. Additionally, the number of available animal models for SCI has enhanced the understanding of the complex pathological mechanisms involved in the generation of chronic inflammatory pain in SCI. These findings enable us to identify and validate several potent natural analgesic-anti-inflammatory drug candidates with minimal side effects. However, until now, these compounds have been studied in preclinical models and shown promising results but no clinical studies have been performed. Therefore, a detailed exploration of these natural compounds is important for bringing them from bench to bedside.

Keywords: Natural products, CB receptors, cysteine–cysteine chemokine ligand 21, dorsal horn neuron hyperexcitability and central sensitization.

Rights & PermissionsPrintExport Cite as

Article Details

Published on: 22 December, 2020
(E-pub Ahead of Print)
DOI: 10.2174/1874467213666201223111743
Price: $95

Article Metrics

PDF: 224