Heterocyclic compounds and their derivatives gained more attention due to their valuable
biological and pharmacological properties. Benzothiazole is a heterocyclic structure containing a bicyclic
ring system with a large panel of applications. The benzothiazole is present in many new products
undergoing research hoping that it possesses various biological activities.
Epilepsy is a diverse group of diseases marked by neuronal excitability and hypersynchronous neuronal
activity of motor, sensory or autonomic events with or without loss of consciousness.
Presently, many antiepileptic drugs like lamotrigine, stiripentol tiagabine, pregabalin, felbamate, and
topiramate are available and effective towards 60-80% of patients only, along with undesirable side
effects, such as hepatotoxicity, gastrointestinal disturbance, drowsiness, gingival hyperplasia, and hirsutism.
Thus, many attempts are still on-going to develop antiepileptic drugs with a safer profile.
This review is mainly focused on the compilation of reported scientific literature data in the recent
one-decade on the anticonvulsant activity of benzothiazole compounds.