Recent Development in Substituted Benzothiazole as an Anticonvulsant Agent

Author(s): Amol Kale*, Rajendra Kakde, Smita Pawar, Rutuja Thombare

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 21 , Issue 8 , 2021


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Abstract:

Heterocyclic compounds and their derivatives gained more attention due to their valuable biological and pharmacological properties. Benzothiazole is a heterocyclic structure containing a bicyclic ring system with a large panel of applications. The benzothiazole is present in many new products undergoing research hoping that it possesses various biological activities.

Epilepsy is a diverse group of diseases marked by neuronal excitability and hypersynchronous neuronal activity of motor, sensory or autonomic events with or without loss of consciousness.

Presently, many antiepileptic drugs like lamotrigine, stiripentol tiagabine, pregabalin, felbamate, and topiramate are available and effective towards 60-80% of patients only, along with undesirable side effects, such as hepatotoxicity, gastrointestinal disturbance, drowsiness, gingival hyperplasia, and hirsutism. Thus, many attempts are still on-going to develop antiepileptic drugs with a safer profile.

This review is mainly focused on the compilation of reported scientific literature data in the recent one-decade on the anticonvulsant activity of benzothiazole compounds.

Keywords: Benzothiazole, substituted benzothiazoles, anticonvulsant agent, anticonvulsant, pharmacophore, seizures.

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Article Details

VOLUME: 21
ISSUE: 8
Year: 2021
Published on: 22 December, 2020
Page: [1017 - 1024]
Pages: 8
DOI: 10.2174/1389557521666201222145236
Price: $65

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