Cell Arrest and Apoptosis Induced by the Next Generation of Vanadium Based Drugs: Action Mechanism to Structure Relation and Future Perspectives

(E-pub Ahead of Print)

Author(s): Manos C. Vlasiou*, Kyriaki S. Pafiti

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)


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Abstract:

Background: Every year we encounter more projects indicating the promising anticancer activity of vanadium molecules against different types of cancer cells. The new generation of metal-based drugs are targeting the energy supplies of the cell through ROS generation leading them to cell arrest and apoptosis. The relatively low toxicity of vanadium metal, the different oxidation states that it can be occurred and in general, the lipophilicity of transition metals, gave attention to vanadium after the exhausted research in platinumbased drugs. Herein, we are reviewing the latest advances in apoptotic activity of vanadium complex molecules and trying to reveal the structure to action relationship. Future perspectives of vanadium anticancer drugs also discussed.

Methods: Data were collected from Web of Science, Scopus, Pubmed, through searching of these keywords: “apoptosis”, “anticancer drugs”, “vanadium complexes”, “synthesis” and “cell arrest”.

Results: A good amount of vanadium complexes gave promising results over the last years showing that a more careful approach of a ligand design, could give a rise to the next generation of vanadium drugs.

Conclusion: The low toxicity of vanadium ion in combination with its V(IV) species selectivity, gives to the vanadium, a head starts against other transition metal complexes.

Keywords: Vanadium, apoptosis, metallodrugs, anticancer, ROS, mitochondria

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Article Details

Published on: 22 December, 2020
(E-pub Ahead of Print)
DOI: 10.2174/1871520621666201222143839
Price: $95

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