Significance of 1,3,4-Oxadiazole Containing Compounds in New Drug Development

(E-pub Ahead of Print)

Author(s): Kavita Rana*, Salahuddin, Jagdish K. Sahu

Journal Name: Current Drug Research Reviews
(Formerly Current Drug Abuse Reviews)

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Background: Oxadiazole core displays various pharmacological properties among five membered nitrogen heterocyclic compounds specially 1,3,4-oxadiazole containing molecules have occupied a particular place in the field of synthetic medicinal chemistry as surrogates (bioisosteres) of carboxylic acids, carboxamides and esters. Moreover, they are having widespread kind of applications in numerous zones as polymers, as luminescence producing materials and as electron-transporting materials and corrosion inhibitors.

Methods: This write up contains comprehensive and extensive literature survey on chemical reactivity and biological properties associated with 1,3,4-oxadiazole containing compounds.

Results: This review summarises 1,3,4-oxadiazole moiety in numerous compounds with reported pharmacological activity such as antiviral, analgesic and anti-inflammatory, antitumor, antioxidant, insecticidal and anti-parasitic etc. Nevertheless, ring opening reactions of the 1,3,4-oxadiazole core have also made great attention, as they produce new analogues containing aliphatic nitrogen atom and to other ring system.

Conclusion: In relation to occurrence of oxadiazoles in biologically active molecules, 1,3,4-oxadiazole core emerges as an structural subunit of countless significance and usefulness for the development of new drug aspirants applicable to the treatment of many diseases. It concludes that 1,3,4-oxadiazole core compounds are more efficacious and less toxic medicinal agents with respect to new opinions in the search for rational strategies.

Keywords: 1, 3, 4-oxadiazole, heterocyclic, anticancer, antimicrobial, anti-tubercular, analgesic and anti-inflammatory1, 3, 4-oxadiazole, heterocyclic, anticancer, antimicrobial, anti-tubercular, analgesic and anti-inflammatory

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Article Details

Published on: 21 December, 2020
(E-pub Ahead of Print)
DOI: 10.2174/2589977512666201221162627
Price: $95

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