Background: Oxadiazole core displays various pharmacological properties among five membered nitrogen
heterocyclic compounds specially 1,3,4-oxadiazole containing molecules have occupied a particular place in the field of
synthetic medicinal chemistry as surrogates (bioisosteres) of carboxylic acids, carboxamides and esters. Moreover, they are
having widespread kind of applications in numerous zones as polymers, as luminescence producing materials and as
electron-transporting materials and corrosion inhibitors.
Methods: This write up contains comprehensive and extensive literature survey on chemical reactivity and biological
properties associated with 1,3,4-oxadiazole containing compounds.
Results: This review summarises 1,3,4-oxadiazole moiety in numerous compounds with reported pharmacological activity
such as antiviral, analgesic and anti-inflammatory, antitumor, antioxidant, insecticidal and anti-parasitic etc. Nevertheless,
ring opening reactions of the 1,3,4-oxadiazole core have also made great attention, as they produce new analogues
containing aliphatic nitrogen atom and to other ring system.
Conclusion: In relation to occurrence of oxadiazoles in biologically active molecules, 1,3,4-oxadiazole core emerges as an
structural subunit of countless significance and usefulness for the development of new drug aspirants applicable to the
treatment of many diseases. It concludes that 1,3,4-oxadiazole core compounds are more efficacious and less toxic medicinal
agents with respect to new opinions in the search for rational strategies.