Background: Corticosteroids are an important group of polycyclic compounds having a wide range of
pharmacological and physiological properties. Thiopyran derivatives are important building blocks of many biologically
Objective: Keeping in mind the wide range of applications of corticosteroids and thiopyran, herein we intend to
develop a simple and efficient strategy to synthesize steroidal thiopyran derivatives starting with different commercially
available corticosteroids and study their biological properties.
Materials and Methods: To achieve our aim, we employed a one-pot multi-component synthesis of steroidal thiopyran
derivatives by the reaction of corticosteroids, malononitrile, and carbon disulphide in the presence of triethylamine
as a catalyst.
Results and Discussion: An array of novel thiopyran compounds was obtained with the highest product yield
using Et3N. Scanning electron microscopy analysis manifested agglomeration pertaining to brick-shaped crystals
of corticosteroid thiopyran. Synthesized compounds were also found to be active as anti-bacterial agents.
Conclusion: We describe a facile one-pot multi-component synthesis of corticosteroid thiopyran derivatives,
which are found to possess anti-bacterial activity. Excellent yields of the products, simple work-up, easily available
starting materials, and non-chromatographic purification are some of the main advantages of this protocol.