Stem cell therapy efficiently targets the brain for most neurological disorders like migraine,
Parkinsonism, schizophrenia, Alzheimer’s disease, and brain injury. The major obstacles in
potential brain targeting are the physiological barriers like blood-brain-barrier and bloodcerebrospinal
fluid barrier. The conventional injectable route or direct transplantation of stem cells
results in brain injury and is less feasible clinically. The alternative to these invasive routes is the
intranasal route that is non-invasive, easily repeatable technique and highly effective in brain targeting
without crossing the blood-brain barrier. Extensive research has been undertaken for the delivery
of stem cells to the brain via the intranasal route that holds great potential in overcoming the existing
barriers. Nanotechnology is emerging as a novel interdisciplinary field in the arena of stem
cell research. The combination of nanotechnology coupled with stem cell therapy has led to synergistic
outcomes in diagnostic and therapeutic applications of neurological diseases. This review
provides insights into stem cell-based nanotherapy for brain targeting via the intranasal route.
Keywords: Intranasal delivery, stem cells, blood-brain barrier, brain targeting, nanotechnology, neurological disorders.
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