Background: Congenital heart diseases are the most prevalent congenital abnormalities in the neonates, caused
by the environmental and genetic factors and contribute to the leading cause of death. The aim of this study is to evaluate
the relationship between neonates with large for gestational age and increased risk of congenital heart diseases among nondiabetic mothers.
Methods: In this study, 179 neonates with large for gestational age in Khorramabad were enrolled where heart
abnormalities were evaluated using echocardiography.
Results: 87 neonates had more than 4000 g of the birth weight with no heart abnormalities and 92 (51%) macrosomic
neonates had congenital heart diseases. Statistical analysis revealed that there was a significant relationship between birth
weight and increased risk of acquiring congenital heart disease between the two groups. There was no significant
relationship between birth weight, maternal age, gender, labor type and blood group between the two groups. The highest
incidence of congenital heart anomalies was related to 38% of arterial septal defect (ASD) and 15.2% of ASD and VSD,
Conclusion: The most prevalent abnormality was arterial septal ASD. None of these abnormalities were associated with
maternal age, birth weight and neonate gender. Future studies for congenital heart disease and neonatal birth weight are