An Updated Review on COVID-19

(E-pub Ahead of Print)

Author(s): Mahmoud Ahmed Ebada*, Ahmed Wadaa-Allah, Eshak Bahbah, Ahmed Negida

Journal Name: Infectious Disorders - Drug Targets
Formerly Current Drug Targets - Infectious Disorders


Article ID: e160921189190
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Abstract:

Coronavirus Disease (COVID-19) pandemic has affected more than seven million individuals in 213 countries worldwide with a basic reproduction number ranging from 1.5 to 3.5 and an estimated case fatality rate ranging from 2% to 7%. A substantial proportion of COVID-19 patients are asymptomatic; however, symptomatic cases might present with fever, cough, and dyspnoea or severe symptoms up to acute respiratory distress syndrome. Currently, RNA RT-PCR is the screening tool, while bilateral chest CT is the confirmatory clinical diagnostic test. Several drugs have been repurposed to treat COVID-19, including chloroquine or hydroxychloroquine with or without azithromycin, lopinavir/ritonavir combination, remdesivir, favipiravir, tocilizumab, and EIDD-1931. Recently, Remdesivir gained FDA emergency approval based on promising early findings from the interim analysis of 1063 patients. The recently developed serology testing for SARSCoV-2 antibodies opened the door to evaluate the actual burden of the disease and to determine the rate of the population who have been previously infected (or developed immunity). This review article summarizes current data on the COVID-19 pandemic starting from the early outbreak, viral structure and origin, pathogenesis, diagnosis, treatment, discharge criteria, and future research.

Keywords: Coronavirus, Epidemiology, Pandemic, COV-SARS-2, COVID-19, Public healthCoronavirus, Epidemiology, Pandemic, COV-SARS-2, COVID-19, Public health

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Article Details

Article ID: e160921189190
(E-pub Ahead of Print)
DOI: 10.2174/1871526520666201216165322
Price: $95

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