Background: SARS-CoV-2 is a pandemic now and several preventive and control measures have been taken by
several countries to contain and treat the disease. WHO has been working meticulously and have been providing up to date
information and statistics on incidences and death. Several broad spectrum anti-viral drugs are available and have been used
in the past to fight against the viral outbreak. Recently Remdesivir, an experimental prodrug from Gilead Sciences have
been found potential to be used as a therapy to treat the COVID-19.
Objective: Here we have reviewed the previous findings that are available in the literature and report several findings that
are crucial and provide up to date information.
Result: Remdesivir was initially invented for use against Ebola virus treatment and has proved potential against different
strains of Ebola, Nipah, and other strains of coronaviruses. Clinical trials with Remdesivir for COVID-19 patients have
begun and several off label use of Remdesivir is reported recently. Currently the drug seems to have effect against the
SARS-CoV-2 virus with side effects among few patients. The results although are not conclusive are partly promising. This
review provides past and recent updates on the use of Remdesivir.
Conclusion: From the review we conclude that the drug Remdesivir is known to exhibit its mechanism of action by
terminating the RNA synthesis and it is a potential drug against the novel corona virus.