Background: Many observations denote that we should deal with COVID-19 as a systemic
Methods: In the following report, we briefly discuss observations denoting “the systemic” nature
Results: COVID-19 virology, the roles of ACE-2 receptor in COVID-19 pathogenesis, immunological
aspects of the disease, endothelial dysfunction and coagulopathy, and autopsy studies denote
the systemic nature of COVID-19.
Conclusion: Thinking of COVID-19 as a systemic disease, we will implement our ways of understanding
and hence dealing with that disease. The most important public health solution is an effective
vaccine for the broad population remaining at risk. As patients with COVID-19 present a
broad spectrum of clinical presentation and distinct phenotypes, different strategies of management
should be customized to the specific individual phenotypes. Further researches are highly needed
to clarify the concept of “Is COVID-19 a systemic disease?”. Until that time, we think that clinicians
should deal with COVID-19 as a systemic disease.