Background: Inflammation is a multifactorial process reflecting the response of the organism
to various stimuli and is associated with a number of disorders such as arthritis, asthma and psoriasis,
which require long-lasting or repeated treatment.
Objective: The aim of this paper is to evaluate the anti-inflammatory activity of previous synthesized
thiazole-based chalcone derivatives.
Methods: Chalcones were synthesized via Cliazen-Schmidt condensation1-(4-methyl-2-
alkylamino)thiazol-5-yl) ethanone with a corresponding aromatic aldehyde. For the evaluation of
possible anti-inflammatory activity, carrageenan mouse paw edema was used.
Results: Eight out of thirteen tested chalcones showed anti-inflammatory activity in a range of 51-
55%. Prediction of toxicity revealed that these compounds are not toxic.
Conclusion: In general, it can be concluded that these compounds can be used for further modifications
in order to develop more active and safe agents.