Recent Advances in the Development of 1,2,3-Triazole-containing Derivatives as Potential Antifungal Agents and Inhibitors of Lanoster ol 14α-Demethylase

Author(s): Michelyne Haroun*, Christophe Tratrat*, Hafedh Kochkar, Anroop B. Nair

Journal Name: Current Topics in Medicinal Chemistry

Volume 21 , Issue 6 , 2021


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Abstract:

1,2,3-Triazole, a five-membered heterocyclic nucleus, is widely recognized as a key chromophore of great value in medicinal chemistry for delivering compounds possessing innumerable biological activities, including antimicrobial, antitubercular, antidiabetic, antiviral, antitumor, antioxidants, and anti-inflammatory activities. Mainly, in the past years, diverse conjugates carrying this biologically valuable core have been reported due to their attractive fungicidal potential and potent effects on various infective targets. Hence, hybridization of 1,2,3-triazole with other antimicrobial pharmacophores appears to be a judicious strategy to develop new effective anti-fungal candidates to combat the emergence of drug-sensitive and drug-resistant infectious diseases. Thus, the current review highlights the recent advances of this promising category of 1,2,3-triazole-containing hybrids incorporating diverse varieties of bioactive heterocycles such as conozole, coumarin, imidazole, benzimidazole, pyrazole, indole, oxindole, chromene, pyrane, quinazoline, chalcone, isoflavone, carbohydrates, and amides. It underlies their inhibition behavior against a wide array of infectious fungal species during 2015-2020.

Keywords: 1, 2, 3-triazole, Hybrid compounds, Fungal growth inhibition, Pathogenic fungi, Pharmacomodulation, Molecular modeling.

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Article Details

VOLUME: 21
ISSUE: 6
Year: 2021
Published on: 08 April, 2021
Page: [462 - 506]
Pages: 45
DOI: 10.2174/1568026621999201214232018
Price: $65

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