Impact of Endothelial NOS VNTR Variant on Susceptibility to Diabetic Neuropathy and Type 2 Diabetes Mellitus

Author(s): Serbulent Yigit*, Ayse Feyda Nursal, Suheyla Uzun, Husniye Rustemoglu, Payam Amiri Dashatan, Huseyin Soylu, Aysegul Atmaca, Aydin Rustemoglu, Nilufer Kuruca, Nevin Karakus

Journal Name: Current Neurovascular Research

Volume 17 , Issue 5 , 2020

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Graphical Abstract:


Purpose: The aim of this study was to evaluate whether the VNTR intron 4b/4a variant in the eNOS gene is associated with type 2 diabetes mellitus (T2DM) and DPN.

Methods: A total of 598 subjects were enrolled in the study. eNOS VNTR 4b/4a variant was genotyped by polymerase chain reaction (PCR) method.

Results: eNOS VNTR intron 4b/4b genotype and b allele increased in patients with both DPN and T2DM compared healthy controls (p=0.0005, OR:1.94, p= 0.000002, OR:4.10, respectively). 4a/4b genotype was more prevalent in controls than in DPN and T2DM patients (p=0.00008, OR:0.46; p=0.000004, OR:0.24, respectively). eNOS VNTR b allele was more common in DPN patients and T2DM patients compared with controls (p=0.007, p=0.00002, respectively).

Conclusion: The eNOS VNTR “4b/4b” homozygous genotype and hence “4b”allele as a genetic risk factor for T2DM and DPN, which may serve as a useful marker of increased susceptibility to the risk of these disorders.

Keywords: Endothelial NOS VNTR variant, diabetes mellitus, hyperglycemia, diabetic peripheral neuropathy, genotype, peripheral nerve.

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Article Details

Year: 2020
Published on: 14 December, 2020
Page: [700 - 705]
Pages: 6
DOI: 10.2174/1567202617999201214230147
Price: $65

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