Review on Diagnostic Methods for SARS-CoV-2

(E-pub Ahead of Print)

Author(s): Chandrashekhar Chauriya, Mahesh Sahu, Anuj Kumar Singh, Amita Verma*

Journal Name: Coronaviruses
The World's First International Journal Dedicated to Coronaviruses


Article ID: e170821189088
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Abstract:

Background: In December 2019, a large number of patients with a novel coronavirus were identified in Wuhan, China. The novel coronavirus (COVID-19) is highly contagious and increasing the rate of mortality day by day. The World Health Organization declared

COVID-19 as a worldwide pandemic on March 11, 2020. Early diagnosis, of SARS-CoV-2, can restrict the COVID-19 pandemic.

Objective: We aim to study the currently available diagnostic methods for COVID-19.

Methods: World Health Organisation portal, Centre for Disease control and prevention portal, Indian Council of Medical Research portal, Chinese Centre for Disease Control and prevention portal, Science Direct, Google Scholar, Research Gate, etc. were searched for obtaining data.

Results: Rapid diagnosis and prompt treatment can reduce the number of prospective cases. The diagnostic strategy encompasses the screening of virus with nucleic acid amplification test (NAAT) such as real-time reverse-transcription polymerase chain reaction (RT-PCR) assays. Serological testing is a diagnostic procedure used for identifying the presence of an immune responses. Radiological findings in individuals with COVID-19 were characterised by multiple areas of consolidation in chest. Rapid antigen tests are in- vitro diagnostics have been designed to give results within 10–20 min.

Conclusion: Rapid, simple, and safe diagnosis of COVID-19 has a great impact on deciding clinical and epidemiological factors. RT-PCR results often require 5 to 6 hours. Diagnosis of by serological testing is not suitable but they are important epidemiologically. At present, the best radiological strategy remains undefined. Rapid antigen tests have limitations on sensitivity.

Keywords: COVID 19, diagnosis, RT-PCR, serology, radiological findings.

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Article Details

Article ID: e170821189088
Published on: 11 December, 2020
(E-pub Ahead of Print)
DOI: 10.2174/2666796701999201211213517

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