Ethanolamine: A Potential Promoiety with Additional Effects in the Brain

(E-pub Ahead of Print)

Author(s): Asfree Gwanyanya, Christie Nicole Godsmark, Roisin Kelly-Laubscher*

Journal Name: CNS & Neurological Disorders - Drug Targets
Formerly Current Drug Targets - CNS & Neurological Disorders


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Abstract:

Ethanolamine is a bioactive molecule found in several cells, including those in the central nervous system (CNS). In the brain, ethanolamine and ethanolamine-related molecules have emerged as prodrug moieties that can promote drug movement across the blood-brain barrier. This improvement in the ability to target drugs to the brain may also mean that in the process ethanolamine concentrations in the brain are increased enough for ethanolamine to exert its own neurological ac-tions. Ethanolamine and its associated products have various positive functions ranging from cell signaling to molecular storage, and alterations in their levels have been linked to neurodegenerative conditions such as Alzheimer’s disease. This mini-review focuses on the effects of ethanolamine in the CNS and highlights the possible implications of these effects for drug design.

Keywords: Ethanolamine, brain, CNS, phospholipids, prodrug, synaptic, neuromodulator

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Article Details

Published on: 11 December, 2020
(E-pub Ahead of Print)
DOI: 10.2174/1871527319999201211204645
Price: $95

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