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CNS & Neurological Disorders - Drug Targets

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ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

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Mini-Review Article

Ethanolamine: A Potential Promoiety with Additional Effects on the Brain

Author(s): Asfree Gwanyanya, Christie Nicole Godsmark and Roisin Kelly-Laubscher*

Volume 21, Issue 2, 2022

Published on: 11 December, 2020

Page: [108 - 117] Pages: 10

DOI: 10.2174/1871527319999201211204645

Price: $65

Abstract

Ethanolamine is a bioactive molecule found in several cells, including those in the central nervous system (CNS). In the brain, ethanolamine and ethanolamine-related molecules have emerged as prodrug moieties that can promote drug movement across the blood-brain barrier. This improvement in the ability to target drugs to the brain may also mean that in the process, ethanolamine concentrations in the brain are increased enough for ethanolamine to exert its own neurological actions. Ethanolamine and its associated products have various positive functions ranging from cell signaling to molecular storage, and alterations in their levels have been linked to neurodegenerative conditions such as Alzheimer’s disease. This mini-review focuses on the effects of ethanolamine on the CNS and highlights the possible implications of these effects for drug design.

Keywords: Ethanolamine, brain, CNS, phospholipids, prodrug, synaptic, neuromodulator

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Graphical Abstract

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