Background: Glucose detection is of great significance in biomedicine. In clinical
medicine, diabetes seriously endangers human health. By accurately measuring the blood glucose
content of diabetic patients, diabetes can be effectively monitored and treated. At present, there are
many methods for measuring glucose content, such as chromatography, spectroscopy, and electrochemical
methods. Among them, electrochemical glucose sensors are widely used because of their
high reliability, low cost, and easy operation.
Methods: Combining graphene with other nanomaterials (including graphene, metal oxides, semiconductor
nanoparticles, polymers, dye molecules, ionic liquids and biomolecules) is an effective
way to expand or enhance the sensing performance.
Results: The composite of graphene and nanomaterials is an effective way to enhance the functionality
of the electrochemical sensor. Graphene can accelerate electron transfer and realize direct electrochemistry
and biological sensing. At the same time, graphene derivatives with rich composition
and structure provide the possibility to further regulate their electrochemical performance. These
graphene composite-based biosensors have shown excellent sensitivity and selectivity for glucose
Conclusion: Electrochemical glucose sensors based on graphene composite have received extensive
attention. Although these materials have made significant progress in improving the sensitivity,
lowering the detection limit and broadening the linear range, there are still facing challenges
that require further study.