Advances in Microbiome Detection Technologies and Application in Antirheumatic Drug Design

Author(s): Xin Wu, Xiang Chen, Xiaochen Lyu, Hao Zheng*

Journal Name: Current Pharmaceutical Design

Volume 27 , Issue 7 , 2021


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Abstract:

Rheumatic diseases are a kind of chronic inflammatory and autoimmune disease affecting the connection or supporting structures of the human body, such as the most common diseases Ankylosing spondylitis (AS), gout and Systemic lupus erythematosus (SLE). Although the precise etiology and pathogenesis of the different types of rheumatic diseases remain mostly unknown, it is now commonly believed that these diseases are attributed to some complex interactions between genetics and environmental factors, especially the gut microbiome. Altered microbiome showed clinical improvement in disease symptoms and partially restored to normality after prescribing disease-modifying antirheumatic drugs (DMARDs) or other treatment strategies. Recent advances in next-generation sequencing-based microbial profiling technology, especially metagenomics, have identified alteration of the composition and function of the gut microbiota in patients. Clinical and experimental data suggest that dysbiosis may play a pivotal role in the pathogenesis of these diseases. In this paper, we provide a brief review of the advances in the microbial profiling technology and up-to-date resources for accurate taxonomic assignment of metagenomic reads, which is a key step for metagenomics studies. In addition, we review the altered gut microbiota signatures that have been reported so far across various studies, upon which diagnostics classification models can be constructed, and the drug-induced regulation of the host microbiota can be used to control disease progression and symptoms.

Keywords: Gut microbiome, microbiota, rheumatic diseases, DMARD, NGS, antirheumatic.

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Article Details

VOLUME: 27
ISSUE: 7
Year: 2021
Published on: 02 April, 2021
Page: [891 - 899]
Pages: 9
DOI: 10.2174/1381612826666201211114609
Price: $65

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