Effect of Antihypertensive Drugs on Cognition and Behavioral Symptoms of Patients with Alzheimer’s Disease: A Meta-analysis

Author(s): Roja Rahimi, Shekoufeh Nikfar, Masoud Sadeghi, Mohammad Abdollahi, Reza H. Moghaddam, Mohammad H. Farzaei*

Journal Name: Current Pharmaceutical Biotechnology

Volume 22 , Issue 11 , 2021


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Abstract:

Background: It has been found that there is a link between hypertension and elevated risk of Alzheimer’s Disease (AD). Herein, a meta-analysis based on Randomized Clinical Trials (RCTs) was used to assess the effect of antihypertensive drugs on cognition and behavioral symptoms of AD patients.

Methods: The three databases, PubMed/Medline, Scopus, and Cochrane Library, were searched up to March 2020. The quality of the studies included in the meta-analysis was evaluated by the Jadad score. Clinical Global Impression of Change (CGIC) included in two studies, Mini-Mental State Examination (MMSE) included in three studies, and Neuropsychiatric Inventory (NPI) in three studies were the main outcomes in this systematic review.

Results: Out of 1506 studies retrieved in the databases, 5 RCTs were included and analyzed in the meta-analysis. The pooled mean differences of CGIC, MMSE, and NPI in patients with AD receiving antihypertensive drugs compared to placebo were -1.76 with (95% CI = -2.66 to -0.86; P=0.0001), 0.74 (95% CI = 0.20 to 1.28; P= 0.007), and -9.49 (95% CI = -19.76 to 0.79; P = 0.07), respectively.

Conclusion: The findings of the present meta-analysis show that antihypertensive drugs may improve cognition and behavioral symptoms of patients with AD. However, more well-designed RCTs with similar drugs are needed to achieve more conclusive results.

Keywords: Alzheimer, hypertension, meta-analysis, antihypertensive drugs, cognition, behavioral symptoms.

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Article Details

VOLUME: 22
ISSUE: 11
Year: 2021
Published on: 10 December, 2020
Page: [1511 - 1519]
Pages: 9
DOI: 10.2174/1386207323666201211101720
Price: $65

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