COVID-19 Severity: Lung-Heart Interplay

Author(s): Gayatri Puri, Vikram P. Singh, Amarjit S. Naura*

Journal Name: Current Cardiology Reviews

Volume 17 , Issue 4 , 2021

Article ID: e230421189016
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Graphical Abstract:


In December 2019, a novel COVID-19 infection caused by SARS-CoV-2 has emerged as a global emergency. In a few months, the pathogen has infected millions of people in the world. Primarily SARS-CoV-2 infects the pulmonary system which ultimately leads to ARDS and lung failure. The majority of patients develop milder symptoms but the infection turns severe in a huge number of people, which ultimately results in enhanced mortality in COVID-19 patients. Co-morbid conditions, primarily cardiovascular complications and diabetes, have been reported to show a strong correlation with COVID-19 severity. Further, the onset of myocardial injury secondary to pulmonary damage has been observed in critically ill patients who have never reported heart-related ailments before. Due to drastic health risks associated with virus infection, the unprecedented disruption in normal business throughout the world has caused economic misery. Apparently, newer treatments are urgently needed to combat the virus particularly to reduce the severity burden. Therefore, understanding the crosstalk between lung and heart during COVID-19 might give us better clarity for early diagnosis followed by appropriate treatment in patients with the likelihood of developing severe symptoms. Accordingly, the present review highlights the potential mechanisms that may explain the crosstalk between lung and heart so that effective treatment/management strategies can be evolved swiftly in this direction.

Keywords: COVID-19, SARS-CoV-2, ARDS, cardiovascular disease, respiratory failure, lung-heart interplay.

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Article Details

Year: 2021
Published on: 10 December, 2020
Article ID: e230421189016
Pages: 9
DOI: 10.2174/1573403X16999201210200614
Price: $65

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