Characteristics and Determinants of Pulse Pressure-Age Relationship in Healthy and Non-treated Hypertensive Subjects of Argentinean Population

Author(s): Alejandro Díaz*, Ariel F. Pascaner, Sandra Wray, Edmundo C. Fischer

Journal Name: Current Hypertension Reviews

Volume 17 , Issue 2 , 2021


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Abstract:

Background: The relationship between the increases in pulse pressure (PP) and arterial stiffness determined by aging or systemic hypertension has been widely reported. These findings are supported by large-cohort analyzes conducted in well-known populations, such as Framingham Study. However, there is evidence that an age-PP curvilinear relationship may exist in hypertensive subjects. This study aimed to evaluate the age-related change in pulse pressure and arterial stiffness in a population-based study.

Methods: Carotid-femoral Pulse Wave Velocity (cfPWV) were obtained in 2075 subjects.

Results: Age-related changes of PP showed a curvilinear relationship (R=0.39, p<0.0001) in normotensive subjects, with a nadir at around 50 years of age. On the other hand, the age-cfPWV relationship showed a linear and positive correlation (R=0.72, p<0.0001). PP also showed a curvilinear relationship with age (R=0.36, p<0.0001) in hypertensive subjects, with a nadir around 50 years of age. The age-cfPWV relationship showed a linear and positive correlation (R=0.55, p<0.0001). Similar results were observed in the adult population (age≥16 years). Multivariate analysis showed that age, sex, cfPWV, and mean arterial pressure are determinants of PP values in the entire population; however, this result was not uniform when different subgroups were analyzed.

Conclusion: In conclusion, age-related changes in PP showed a curvilinear relationship and no parallelism with the age-cfPWV relationship for both normotensive and hypertensive subjects. The determinants of PP impact it differently depending on age and the pathological condition of the subject.

Keywords: Pulse pressure, pulse wave velocity, arterial, stiffness, ageing, cfPWV, hypertension.

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Article Details

VOLUME: 17
ISSUE: 2
Year: 2021
Published on: 10 December, 2020
Page: [137 - 148]
Pages: 12
DOI: 10.2174/1573402116999201210195123
Price: $65

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