Pathways Related to the Anti-Cancer Effects of Metabolites Derived from Cerrado Biome Native Plants: An Update and Bioinformatics Analysis on Oral Squamous Cell Carcinoma

Author(s): Guilherme Machado Xavier, André Luiz Sena Guimarães*, Carlos Alberto de Carvalho Fraga*, Talita Antunes Guimarães, Marcela Gonçalves de Souza, Kimberly Marie Jones, Lucyana Conceição Farias

Journal Name: Protein & Peptide Letters

Volume 28 , Issue 7 , 2021


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Graphical Abstract:


Abstract:

Background: Oral cancer is a significant health problem worldwide. Oral squamous cell carcinoma (OSCC) is a malignant neoplasm of epithelial cells that mostly affects different anatomical sites in the head and neck and derives from the squamous epithelium or displays similar morphological characteristics. Generally, OSCC is often the end stage of several changes in the stratified squamous epithelium, which begin as epithelial dysplasia and progress by breaking the basement membrane and invading adjacent tissues. Several plant-based drugs with potent anti-cancer effects are considered inexpensive treatments with limited side effects for cancer and other diseases.

Objective: The aim of this review is to explore whether some Brazilian plant extracts or constituents exhibit anti-tumorigenic activity or have a cytotoxic effect on human oral carcinoma cells.

Methods: Briefly, OSCC and several metabolites derived from Brazilian plants (i.e., flavonoids, vinblastine, irinotecan, etoposide and paclitaxel) were used as keywords to search the literature on PubMed, GenBank and GeneCards.

Results: The results showed that these five chemical compounds found in Cerrado Biome plants exhibit anti-neoplastic effects. Evaluating the compounds revealed that they play a main role in the regulation of cell proliferation.

Conclusion: Preserving and utilising the biodiversity of our planet, especially in unique ecosystems, such as the Cerrado Biome, may prove essential to preserving and promoting human health in modern contexts.

Keywords: OSCC, HNSCC, Brazilian plants, TP53, cytotoxic effect, anti-cancer effects.

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Article Details

VOLUME: 28
ISSUE: 7
Year: 2021
Published on: 09 December, 2020
Page: [735 - 749]
Pages: 15
DOI: 10.2174/0929866527999201209221012
Price: $65

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