Isatin Hybrids and Their Pharmacological Investigations

Author(s): Bhushan D. Varpe, Amol A. Kulkarni*, Shailaja B. Jadhav, Anil S. Mali, Shravan Y. Jadhav

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 21 , Issue 10 , 2021

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Graphical Abstract:


Hybridization is an important strategy to design molecules that can be effectively used to treat fatal diseases known to mankind. Molecular hybrids and their pharmacological investigations aided in discovering several potent isatin (Indole 2, 3 dione) derivatives with anti-HIV, antimalarial, antitubercular, antibacterial, and anticancer activities. Indole-2,3-dione and their derivatives have diverse pharmacological properties and have a prominent role in the discovery of new drugs. To understand the various approaches for designing new molecules based on isatin nucleus analysis of various pharmacophore hybrids, spacers/linkers between pharmacophores and isatin for hybridization and their biological activities are important. This review discusses the progress in developing isatin hybrids as biologically effective agents and their crucial aspects of design and structure-activity relationships.

Keywords: Hybridization, Molecular hybrids, anticancer, anti-HIV, antimalarial, antitubercular, antibacterial.

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Article Details

Year: 2021
Published on: 09 December, 2020
Page: [1182 - 1225]
Pages: 44
DOI: 10.2174/1389557520999201209213029
Price: $65

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