Coronavirus Disease 2019: Virology and Drug Targets

(E-pub Ahead of Print)

Author(s): Praveen Thaggikuppe Krishnamurthy*

Journal Name: Infectious Disorders - Drug Targets
Formerly Current Drug Targets - Infectious Disorders

Article ID: e160921188929
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The Coronavirus Disease 2019, a pandemic caused by novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is seriously affecting global health and the economy. As the vaccine development takes time, the current research is focused on repurposing FDA approved drugs against the viral target proteins. This review discusses the current understanding of SARS-CoV-2 virology, its target structural proteins (S- glycoprotein), non-structural proteins (3- chymotrypsin-like protease, papain-like protease, RNA-dependent RNA polymerase, and helicase) and accessory proteins, drug discovery strategies (drug repurposing, artificial intelligence, and high-throughput screening), and the current status of antiviral drug development.

Keywords: SARS-CoV-2, CoVID-19, Drug targets, VirologySARS-CoV-2, CoVID-19, Drug targets, Virology

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Article Details

Article ID: e160921188929
(E-pub Ahead of Print)
DOI: 10.2174/1871526520666201209145302
Price: $95

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