In December 2019, a novel coronavirus named severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) rapidly infected a large population in Wuhan city, Hubei province, China.
Since then, it has been spread all over the world, causing a pandemic termed as Coronavirus Disease
2019 or COVID-19. It has infected over 32 million people and caused more than nine lakhs casualties
worldwide to date. Till now, no specific drug or vaccine has been developed to prevent the
spread of SARS-CoV-2. WHO has announced that maintaining personal hygiene and social distancing
are the best available options against COVID-19. Various experimental and re-purposed drugs
are being used as preventive and supportive therapy in different parts of the world. Comprehensive
information about SARS-CoV-2 is required to develop therapeutic approaches for the prevention
of COVID-19. In this article, we have comprehensively reviewed the origin, structure, and infection
mechanism of SARS-CoV-2. We have also discussed the pathology of COVID-19, and various
therapeutic interventions that are being used for drug development against COVID-19.