SARS-CoV-2: Origin, pathogenesis and Therapeutic Interventions

(E-pub Ahead of Print)

Author(s): Ipsita G Kundu, NNV Radharani, Amit S Yadav, Srinivas Patnaik, Gopal C Kundu*

Journal Name: Coronaviruses
The World's First International Journal Dedicated to Coronaviruses


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Abstract:

In December, 2019 a novel coronavirus named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) rapidly infected a large population in Wuhan city, Hubei province, China. Since then it has been spread all over the world causing a pandemic termed as Coronavirus Disease 2019 or COVID-19. It has infected over 32 million people and caused more than nine lakhs casualties worldwide till date. Till now there is no specific drug or vaccine has been developed to prevent the spread of SARS-CoV-2. WHO has announced that personal hygiene and social distancing are the best available options against COVID-19 till now. Various experimental and re-purposed drugs are being used as preventive and supportive therapy in different parts of world. Comprehensive information about SARS-CoV-2 is required to develop therapeutic approaches for prevention of COVID-19. In this article, we have comprehensively reviewed the origin, structure and infection mechanism of SARS-CoV-2. We have also discussed the pathology of COVID-19 and various therapeutic interventions which are being used for drug development against COVID-19.

Keywords: Coronavirus, SARS-CoV-2, COVID-19, Pandemic, therapy and management

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/2666796701999201209144207